Everything about Microspheres
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  • Phosphorescent Microspheres – Long Afterglow Particles

    Phosphorecent Beads - Yellow Green Afterglow Spheres

    Phosphorecent Beads - Yellow Green Afterglow

    Phosphorescent microspheres in particle sizes 10 to 600 microns are now available from Cospheric LLC. These phosphorescent particles are 90% spherical and appear to be off-white under ordinary daylight or regular room illumination.  However, when the lights are turned off these phosphorescent particles exhibit phosphorescent yellow-green after-glow.

    The spheres have tight particle size distributions and are > 90% within size range.  Polymer spheres that incorporate proprietary phosphorescent ingredient have a melting point of 115°C , and are mechanically stable past 90°C.  Phosphorescent beads are also inert in most solvents.

    Phosphorescent Decay CurveIntensity of Phosphorescent Afterglow:

    Intensity according to DIN 67510-1

    800 mcd/m2 at 1 minute
    180 mcd/m2 at 5 minutes
    90 mcd/m2 at 10 minutes
    12 mcd/m2 at 1 hour
    5 mcd/m2 at 2 hours

    Excitation and Phosphorescent Emission Curve:
    Excitation and Emission Spectra

  • Density Marker Beads – Microspheres with Specific gravity of 1.065 and 1.075

    Product Announcement:

    Density Marker Beads 1.065 Specific Gravity

    Red 1.065 g/cc Spheres

    In the biomedical industry researchers are sometimes looking for cells having targeted specific gravities.  In order to locate these cells in test tubes it is useful to have colored marker beads which will show where the delineation between specific densities occurs.  Two microsphere products having densities of 1.065 g/cc and 1.075 g/cc were recently released.

    Blue Density Marker Beads with Specific Gravity of 1.075

    Blue 1.075g/cc Spheres

    These spheres are offered with density tolerances of ±0.005 g/cc enabling excellent stratification, and bright blue and red coloration for high visibility with the unaided eye.

    R&D Quantities are in stock and ready to purchase in sizes from 10um to 600um, larger 1kg+ quantities can be made to order to existing specifications or made to your custom color and density requirements. For more information visit:  Blue Density Marker Beads 1.075g/ccRed Density Marker Beads 1.065g/cc.    Additional densities of marker beads are also available in 1.01-1.10g/cc

    Some Materials which have densities close to these markers are1:

    Rat liver cells
    Hepatocytes 1.07–1.10g/ml
    Kupffer cells 1.05–1.06g/ml
    Human  blood cells
    Thrombocytes 1.04–1.06g/ml
    Lymphocytes 1.06–1.08g/ml
    Granulocytes 1.08–1.09g/ml
    Erythrocytes 1.09–1.10g/ml
    E. coli 1.13g/ml
    Tobacco mosaic virus 1.06g/ml
    Equine  abortion virus 1.08g/ml
    Influenza virus 1.06g/ml
    Mitochondria 1.09–1.11g/ml
    Lysosomes 1.04–1.11g/ml
    Peroxisomes 1.05–1.07g/ml
    Synaptosomes 1.04–1.06g/ml
    Nuclei 1.08–1.12g/ml

    1 – Courtesy of Amersham Biosciences

  • Microspheres: Technologies and Global Markets

    An extensive market research report titled Microspheres: Technologies and Global Markets was recently published by BCC Research marketing firm. The microspheres report examines the spherical microparticles used as components in many advanced materials and composites, in the healthcare and personal care industries, and in many specialty research and development applications. The report estimates the size of the microsphere industry worldwide and makes predictions on a 5-year compound annual growth rate of the microsphere market.

    The global market for microspheres in 2010 is estimated to be $2 billion and growing at a 5–year compound annual growth rate (CAGR) of 11.6%, reaching global sales of $3.5 billion by 2015.

    The use of microspheres in medical technology is a relatively new and evolving industry that will see an estimated compound annual growth rate (CAGR) of 24.5% over the next 5 years. This sector is valued at $481 million in 2010 and is expected to reach $1.4 billion by 2015.

    BCC’s analysis suggests that microspheres will see significantly increased demand in the life–sciences markets, which include medicine and biotechnology. The life sciences sector is worth an estimated $203 million in 2010 and is expected to increase at a 9.3% compound annual growth rate (CAGR) to reach $317 million in 2015.

    The key objective of compiling a market research report on microspheres was to present a comprehensive analysis of the global market for microspheres, including analysis of  supply and demand for microspheres across various industries and geographic regions. The report also includes a technical description of a wide variety of types of microspheres available on the market, as well as relevant industries, technologies and applications.
    • Describes demand for microspheres in six major industries: composites; paints and coatings; oil and gas; cosmetics and personal care; biotechnology and life sciences; and medicine and medical devices.
    • Analyses the demand for 2009 and 2010 and forecasts sales over the next 5 years by industry, type of microspheres, and geographic location.
    • Describes different types of microspheres with respect to their chemical composition, including glass, ceramic, and polymer microspheres, and unique material properties that make them suitable for specific industries and applications.
    • Provides detailed descriptions of major players in the market and their product portfolios.
    • Identifies areas of the market that are expected to experience the highest growth in demand.
    • Discusses the history and structure of the industry, technologies, and factors influencing pricing, supply and demand.
    • Reviews price trends and the relationship between price, quality, end–use application and functionality in the microsphere industry.
    • Examines recent advances in technology, newly evolving markets and companies, as well other factors influencing supply.

    This report can be purchased from BCC Research.

    Report Code: AVM073A, Published: November 2010, Analyst: Yelena Lipovetskaya

  • ParaMagnetic Microspheres

    Paramagnetic microspheres have the ability to increase in magnetization with an applied magnetic field and loose their magnetism when the field is removed. Neither hysteresis nor residual magnetization is observed and that provides the end use two very practical advantages:

    • When the filed is removed, the microspheres demagnetize and re-disperse easily. This property allows efficient washing steps, low background and good reproducibility.
    • The behavior of the microspheres is always the same whatever the magnetization cycles may be. Such behavior is a key point for automated instrument.
    Black Paramagnetic Microspheres

    106-125um Magnetic Microspheres

    Recently black paramagnetic microspheres have been produced in larger sizes of 10 micron to 1mm (1000um) and in dry form enabling scientists to leverage the benefits of paramagnetic particles in new applications. These highly spherical polyethylene microspheres offer the flow-ability of standard microspheres, with the ability to be separated from other materials for re-use and cleanup.

    One use of paramagnetic microspheres as large as 1mm in diameter to simulate salmon eggs, Scientists are able to place them in a natural habitat, observe how they move with the water currents and then use their magnetic properties to clean them up.

    SuperParamagnetic microspheres, sometimes just called magnetic microspheres or paramagnetic microspheres have become widely used in the life sciences industry (<10um diameters) for applications such as:

    • Solid Phase Immunoassays
    • Bacteria Detection
    • High Throughput screening
    • Rapid Tests
    • Cell Sorting
    • Biosensors
    • Nucleic Acids Technology
    • Microfluidics1

    Super paramagnetic microspheres used in the life science industry are supplied in solution form.

    1. Merck Estapor Super Paramagnetic Microspheres Brochure

  • Solid Red Polyethylene Microspheres Announced

    Solid Red Polyethylene microspheres 250-300umSanta Barbara, CA –  May 28, 2010 – Cospheric LLC is now offering a product line of solid red polyethylene microspheres in particle size ranges from 10um to 1000um (1mm).

    Offering a bright red color.  These microspheres can be used as additives in personal care products, or in fluid flow visualization experiments.  Samples are in stock and ready to ship to customers for R&D use of product evaluation.  These high quality microspheres are specified to be greater than 90% spherical, and greater than 90% in the specified size range.

    Sample Density is 0.98g/cc (Custom densities are available)

    Spherical Particle sizes include:

    10-27um, 27-32um (30 micron), 32-38um (35 micron), 38-45um (40 micron), 45-53um (50 micron), 53-63um (60 micron), 63-75um (70 micron), 75-90um (80 micron), 90-106um (0.1mm), 106-125um, 125-150um, 150-180um, 180-212um (0.2mm), 212-250um (0.25mm), 250-300um (0.3mm), 300-355um (0.35mm), 355-400um (0.4mm), 400-500um (0.5mm), 500-600um (0.6mm), 600-710um (0.7mm), 710-850um (0.8mm), 850-1000um (0.9mm).