Microspheres Online

Everything about microspheres and research utilizing precision spherical particles.

Motivations for Using Biodegradable Microspheres in Drug Delivery

In recent years there is significant interest in using biodegradable polymeric microspheres for drug delivery. Delivering drugs through biodegradable microspheres has numerous advantages compared to conventional delivery systems. While in conventional systems the drug is usually released shortly after delivery and stops working after a brief period of time, biodegradable polymer offers a way to provide sustained release over a longer time, thus eliminating the need for multiple doses and ensuring sustained and controlled drug delivery over weeks or months.

Chitosan microspheres prepared by spray drying

Spray drying has been used in the production of fine powders from emulsions for many years, but it is not a process in which most people associate the production of microspheres.? This journal article shows how the authors were able to produce highly spherical microspheres in the 2-10um range by controlling the levels of Chitosan and crosslinking agents used.

Chitosan MicrospheresThe key items I found of interest in this article were:

The quality of the microspheres that were produced, as seen the the attached SEM micrograph.

How the process variables did not affect the zeta potential of the microspheres produced (Table 4 below), and how the size can be varied by varying the concentrations of Chitosan or the Molecular weight (MW).

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Chitosan Coated PLGA-Microspheres – A Modular System for Targeted Drug Delivery

During some research on PLGA microspheres we found this interesting article published in European Cells and Materials Vol 7 Suppl 2. 2004 (pages 11-12).?? They were able to achieve a significant change in the zeta potential of their microspheres just by increasing the dosage of Chitosan.?? The authors conclusions and a graph of their data follow.

Discussion and Conclusions by the authors:

The increase in zeta potential from ?70.8 mV (chitosan-free PLGA particles) to +20.5 mV with increasing chitosan concentrations in the W2-phase used for particle preparation strongly suggests that the polycationic chitosan was firmly adsorbed to the particle surface. This finding was confirmed by X-ray photoelectron spectroscopy (data not shown). The coupling of biotin via a NHS-PEGlinker showed that the amino groups of? chitosan represent suitable sites for covalent bioconjugation of different ligands. The process allows the production of particles with a mean diameter between 1 and 10 um, a useful size range for the phagocytosis by? phagocytes like dendritic cells or macrophages.

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Biodegradable microspheres for vitreoretinal drug delivery

One of the microsphere topics that seems to be growing these days is biodegradability.? For those of you who are unfamiliar with the topic an excellent introductory article can be found in: Advance Drug Delivery Reviews 52 (2001) 5-16, called “Biodegradable microspheres for vitreoretinal drug delivery.”? The article does a good job describing the advantages of the various polymers available, such as poly(lactic acid) [PLA], poly(glycolic acid) [PGA], and its copolymer poly(lactic-coglycolic) acid [PLGA].

The article also recommends the prefered sterlization method for drug delivery (the authors recommend irradiation).

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