Microspheres Online

Everything about microspheres and research utilizing precision spherical particles.

Magnetic Microspheres – New Size Ranges Offered

Cospheric announces new particle size ranges for its BKPMS, Paramagnetic Microsphere product.

Thanks to customer demand for narrower particle size ranges of paramagnetic microspheres. Cospheric has added the following sizes to its extensive inventory of microspheres offered in the dry powder form:

Neutrally Buoyant Particles – What Are They, What Are They Used For, How to Use Them?

Suspension of microspheres in water enables the visualization and characterization of fluid flow and testing the capability of devices to withstand particulate matter in the fluid stream, ensuring that microspheres do not settle and do not float on the surface. Most of these polymer microspheres are at least moderately opaque and clearly visible in water, clear or translucent liquids.

Microspheres in Medical Devices – MDDI Magazine

What are Microspheres?

The Microsphere of Influence

Published on MDDI Magazine
By: Yelena Lipovetskaya

Why Use Microspheres in Medical Devices?

Properties of Microspheres - Composition
Microspheres in Medical Devices

Microspheres are round microparticles that typically range from 1 to 1000 micron in diameter. Benefits of microspheres in medical devices, pharmaceuticals, and cosmetics are well known due to the microspheres’ ability to encapsulate and deliver active materials. However, there are many other lesser known advantages and functionalities of using micropsheres in medical device design, quality control, manufacturing, and testing.

The typical manufacturing process involves the microencapsulation of a drug or an active cosmetic ingredient to protect it from the deteriorating effects of the environment or for optimal release and performance in the final product. Active ingredients are released by dissolution of the capsule walls, mechanical rupture (rubbing, pressure, or impact), melting, or digestion processes. The resulting particles are often called microcapsules, which are different from solid, non-deformable microspheres.

Solid microspheres are widely used as fillers and spacers in a variety of industries. Microspheres that are used to manufacture and test medical devices are typically solid particles that are made from robust and stable raw materials such as polymers, glass, and in some cases, ceramics. Different types and grades of microspheres are available and selected based on specific application requirements.

Solid microspheres in medical devices are often used as tracers and challenge particles. In these situations, it is beneficial to use larger microspheres with sphere diameters greater than 50 micron that are vividly colored (red, blue, black, yellow, or green), since they provide contrast with the background material and visibility to the naked eye in daylight.

Colored microspheres are typically used in the testing of filtration media and systems, vial and container cleaning evaluations, flow tracing and fluid mechanics, centrifugation and sedimentation processes, pharmaceutical manufacturing, and contamination control.

Fluorescent microspheres are recommended for applications that require the use of particles that emit distinctive colors when illuminated by UV light and offer additional sensitivity for observation through the use of microscopes, lasers, and other analytical methods. Examples include microcirculation and biological research, imaging, and flow cytometry. Fluorescent microspheres can be excited and detected by a wide range of methods and are useful as experimental particles for acoustical and optical analytical systems.

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ParaMagnetic Microspheres

These highly spherical polyethylene microspheres offer the flow-ability of standard microspheres, with the ability to be separated from other materials for re-use and cleanup.

Metal-Coated Microspheres – Conductive Coating

Metal-Coated Microspheres - Hollow Glass

Electrically conductive microspheres are produced by applying a metallic silver coating to the surface of the microspheres, thus giving the advantages of a metal particle with the additional properties of the core microsphere. Typically hollow glass microspheres are silver coated as this offers the combination of a low density filler and a conductive particle. Coatings with EMI shielding of greater than 45db have been produced by adding as little as 20% by weight of M-18 silver coated microspheres.

Microspheres for Coatings Applications (Opaque Polyethylene)

Microspheres are well known in the coatings industry for their use as low-surface-area fillers that offer benefits in viscosity and density control, solids content, application and flow characteristics.

Hemispherically Coated Spheres

Cospheric LLC, a Santa Barbara-based microtechnology company, recently launched a line of opaque polyethylene microspheres that act as a superior opacifying agent and provide maximum hiding power with just one monolayer of microspheres as small as 40 microns in diameter. Microspheres are manufactured in any color imaginable and even in combinations of two differently colored hemispheres.

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